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J Zhejiang Univ (Med Sci)  2019, Vol. 48 Issue (1): 102-110    DOI: 10.3785/j.issn.1008-9292.2019.02.15
Advances in molecular mechanism of vascular remodeling in pulmonary arterial hypertension
XIAO Li(),TONG Xiaoyong()
Department of Pharmacology, School of PharmaceuticalSciences, Chongqing University, Chongqing 401331, China
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Pulmonary arterial hypertension (PAH) is a clinical hemodynamic syndrome characterized by elevated pulmonary arterial pressure and pulmonary vascular resistance leading to right heart failure and death. Vascular remodeling is the most prominent histopathological feature of PAH, which is regulated by many factors. Endoplasmic reticulum stress, calcium disorder and mitochondrial dysfunction are involved in the vascular cell proliferation and apoptosis by regulating intracellular calcium homeostasis and cellular metabolism. Epigenetic phenomenon such as DNA damage and abnormal expression of miRNA are also involved in the regulation of abnormal proliferation of vascular cells. Vascular cell phenotype switching including endothelial-mesenchymal transition and smooth muscle cell phenotype switching play an important role in abnormal proliferation of vascular cells. Vascular remodeling is produced by a variety of cells and molecular pathways, and aiming at multiple targets which is expected to find a new breakthrough in the treatment of PAH, and to improve abnormal vascular remodeling, delay or even reverse the progression of PAH.

Key wordsHypertension, pulmonary/pathology      Ventricular remodeling      Endoplasmic reticulum stress      Calcium/metabolism      Calmodulin/metabolism      Mitochondria      Epigenesis, genetic      Phenotype      Review     
Received: 30 August 2018      Published: 10 May 2019
CLC:  R543.2  
Corresponding Authors: TONG Xiaoyong     E-mail:;
Cite this article:

XIAO Li,TONG Xiaoyong. Advances in molecular mechanism of vascular remodeling in pulmonary arterial hypertension. J Zhejiang Univ (Med Sci), 2019, 48(1): 102-110.

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关键词: 高血压,肺性/病理学,  心室重构,  内质网应激,  钙/代谢,  钙调蛋白/代谢,  线粒体,  后成说,遗传,  表型,  综述 
微小RNA 肺动脉高压患者中的表达 参与血管重构信号通路 参考文献
miR-21 增加 BMPR2/ miR-21/ RhoB 53



miR-130/310 /miR-204/ STAT3





miR-29b /Mcl-1

miR-29b / CCND2




miR-222/ P27

miR-222/ TIMP3


miR-26b 减少 miR-26b/SRF/CTGF 58



miR-361-5p /ABCA1

miR-361-5p/ JAK2/STAT3


miR138 增加 miR138/TASK1 60
miR-150 减少 miR-150/ HIF-1a 61
miR-221-3p 增加 miR-221-3p/ AXIN2 62




miR-17~92/PHD2/ HIF1α

miR-17~92/PDLIM5/TGF-β3/ pSmad3


miR-23a 增加 miR-23a /BMPR2/Smad1 65
Table 1 Expression of miRNA in patients with pulmonary arterial hypertension and related signaling pathways
Figure 1 Schematic diagram of endothelial-mesenchymal transition
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