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J Zhejiang Univ (Med Sci)  2019, Vol. 48 Issue (1): 34-38    DOI: 10.3785/j.issn.1008-9292.2019.02.06
    
Application of mechanosensitive channels in sonogenetics
HONG Feifan1(),LI Yuezhou1,2()
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Abstract  

As a non-invasive approach, sonogenetics is applied to control neuronal activity. The mechanosensitive channel(MSC), which has low threshold of responding to ultrasound, may be the alternative solution. Sonogenetics is the technique that activates the MSC expressed in targeted neurons by low intensity ultrasound, thus achieve the neuromodulation. In this review, we introduce the mechanosensitive channel of large conductance, transient receptor potential, channels of the two-pore-domain potassium family, Piezo and the recent progress on their application in sonogenetics.



Key wordsIon channels      Electrophysiology      Ultrasonography      Neurophysiology      Neurons      Review     
Received: 21 August 2018      Published: 10 May 2019
CLC:  Q71  
Corresponding Authors: LI Yuezhou     E-mail: hongfeifanhff@qq.com;yuezhou-li@zju.edu.cn
Cite this article:

HONG Feifan,LI Yuezhou. Application of mechanosensitive channels in sonogenetics. J Zhejiang Univ (Med Sci), 2019, 48(1): 34-38.

URL:

http://www.zjujournals.com/med/10.3785/j.issn.1008-9292.2019.02.06     OR     http://www.zjujournals.com/med/Y2019/V48/I1/34


超声遗传学技术中的机械敏感性离子通道

超声遗传学技术是一种非侵入性神经调控手段。机械敏感性离子通道可以被低强度的超声激活而开放,达到调节可兴奋性细胞活性的目的,避免高强度超声对组织器官可能造成的损害。本文着重介绍了大电导机械敏感性离子通道、瞬时受体电位通道、双孔钾通道、Piezo等机械敏感性离子通道在超声神经调控中的研究进展及其应用,以期为超声遗传学研究提供参考。


关键词: 离子通道,  电生理学,  超声检查,  神经生理学,  神经元,  综述 
Figure 1 Mechanism of ultrasonic regulation of neural activity[15]
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