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Journal of ZheJiang University(Medical Science)  2015, Vol. 44 Issue (5): 473-478    DOI: 10.3785/j.issn.1008-9292.2015.09.01
Research progress in toxicology of molecular targeted anticancer drugs
LOU Xiao-e, CHEN Min, YANG Bo
Institute of Pharmacology & Toxicology and Biochemical Pharmaceutics, Zhejiang University, Hangzhou 310058, China
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Objective:Drug therapy is essential for cancer treatment. The molecular targeted anticancer drugs develop rapidly in recent years, since the effectiveness of traditional chemotherapy is unsatisfactory and the adverse reactions are high. However, molecular targeted anticancer drugs would damage the function of heart, liver or lung, and may cause adverse effects such as hand-foot syndrome, which restrains their clinical application. Therefore, it is critical for pharmaceutical toxicology to study the toxicity, the related mechanisms and the preventive measures of molecular targeted anticancer drugs.

Key wordsAntineoplastic agents/toxicity      Protein-tyrosine kinases/antagonists &      inhibitors      Protein-tyrosine kinases/adverse effects      Heart/drug effects      Liver/drug effects      Lung/drug effects      Skin diseases/etiology      Review     
Received: 28 May 2015     
CLC:  R96  
Cite this article:

LOU Xiao-e, CHEN Min, YANG Bo. Research progress in toxicology of molecular targeted anticancer drugs. Journal of ZheJiang University(Medical Science), 2015, 44(5): 473-478.

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关键词: 抗肿瘤药/毒性,  蛋白酪氨酸激酶类/拮抗剂和抑制剂,  蛋白酪氨酸激酶类/副作用,  心脏/药物作用,  肝/药物作用,  肺/药物作用,  皮肤疾病,  综述 
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