Please wait a minute...
Journal of ZheJiang University(Medical Science)  2015, Vol. 44 Issue (3): 349-353    DOI: 10.3785/j.issn.1008-9292.2015.05.18
    
Malnutrition in early life and cardiovascular disease in adulthood
LAO Lin-jiang1, ZHANG Li-yan2, DU Li-zhong1
1. Department of Neonatology, the Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China;
2. Department of Neonatology, Fuzhou Children's Hospital, Fuzhou 350000, China
Download: HTML (   PDF(569KB)
Export: BibTeX | EndNote (RIS)      

Abstract  

Epidemiological and experimental studies have demonstrated that the risk of cardiovascular disease(CVD) in adulthood is influenced by the environment in early life. Intrauterine and early postnatal malnutrition and the following catch-up growth have a long-term effect on blood pressure and endothelial function in adulthood. Well-established prenatal or/and postnatal animal models are used to study the impact of different nutritional intervention on CVD in adulthood. This article reviews the early original cause of chronic CVD in adulthood with the hypothesis of DOHaD(the developmental origins of health and disease), and proposes possible preventions in early life on the basis of this theory.



Key wordsCardiovascular diseases/etiology      Cardiovascular diseases/epidemiology      Fetal development      Malnutrition      Models, animal      Review     
Received: 22 January 2015      Published: 25 May 2015
CLC:  R715  
Cite this article:

LAO Lin-jiang, ZHANG Li-yan, DU Li-zhong. Malnutrition in early life and cardiovascular disease in adulthood. Journal of ZheJiang University(Medical Science), 2015, 44(3): 349-353.

URL:

http://www.zjujournals.com/med/10.3785/j.issn.1008-9292.2015.05.18     OR     http://www.zjujournals.com/med/Y2015/V44/I3/349


生命早期营养不良与成年期心血管功能的关系

流行病学调查和实验研究发现成年期心血管疾病除了与遗传和生活方式相关外,还受生命早期营养环境的影响。宫内和出生后早期营养不良及相伴随的追赶生长模式均影响成年期血压、内皮功能等心血管指标。目前已建立多种出生前和(或)出生后营养干预的动物模型研究不同干预方式对成年期心血管功能的影响。本综述结合“健康与疾病的发育起源”假说相关概念阐述成年期心血管疾病的早期营养起源,并对可能的预防措施提出设想。


关键词: 心血管疾病/病因学,  心血管疾病/流行病学,  胎儿发育,  营养不良,  模型,  动物,  综述 

[1] YANG Z J, LIU J, GE J P, et al. Prevalence of cardiovascular disease risk factor in the Chinese population: the 2007-2008 China National Diabetes and Metabolic Disorders Study[J]. Eur Heart J, 2012,33(2):213-210.
[2] SINGHAL A, COLE T J, LUCAS A. Early nutrition in preterm infants and later blood pressure: two cohorts after randomised trials[J]. Lancet, 2001,357(9254):413-419.
[3] GLUCKMAN P D, HANSON M A.The developmental origins of health and disease[M]. New York: Cambridge University Press,2006:1-5.
[4] CALKINS K, DEVASKAR S U.Fetal origins of adult disease[J]. Curr Probl Pediatr Adolesc Health Care, 2011,41(6):158-176.
[5] HALES C N, BARKER D J.Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis[J]. Diabetologia, 1992,35(7):595-601.
[6] GLUCKMAN P D, HANSON M A.Living with the past: evolution, development, and patterns of disease[J]. Science,2004,305(5691):1733-1736.
[7] 魏克伦,杨于嘉,姚裕家,等.中国城市早产儿流行病学初步调查报告[J].中国当代儿科杂志,2005,7(1):25-28. WEI Ke-Lun, YANG Yu-Jia, YAO Yu-Jia, et al. An initial epidemiologic investigation of preterm infants in cities of China[J]. Chinese Journal of Contemporary Pediatrics,2005,7(1):25-28.(in Chinese)
[8] BARKER D J, OSMOND C,GOLDING J, et al. Growth in utero,blood pressure in childhood and adult life,and mortality from cardiovascular disease[J]. BMJ,1989, 298(6673):564-567.
[9] RICH-EDWARDS J W, STAMPFER M J,MANSON J E, et al. Birth weight and risk of cardiovascular disease in a cohort of women followed up since 1976[J]. BMJ,1997, 315(7105):396-400.
[10] HUXLEY R R, SHIELL A W, LAW C M. The role of size at birth and postnatal catch-up growth in determining systolic blood pressure: a systematic review of the literature[J]. J Hypertens,2000,18(7):815-831.
[11] LEESON C P, KATTENHORN M, MORLEY R, et al. Impact of low birth weight and cardiovascular risk factors on endothelial function in early adult life[J]. Circulation,2001,103(9):1264-1268.
[12] BARKER D J,GLUCKMAN P D,GODFREY K M,et al.Fetal nutrition and cardiovascular disease in adult life[J].Lancet,1993,341(8850):938-941.
[13] NORMAN M, MARTIN H. Preterm birth attenuates association between low birth weight and endothelial dysfunction[J]. Circulation,2003,108(8):996-1001.
[14] DE JONG F, MONUTEAUX M C, VAN ELBURG R M,et al.Systematic review and meta-analysis of preterm birth and later systolic blood pressure[J]. Hypertension, 2012,59(2):226-234.
[15] BROOKE O G, ANDERSON H R, BLAND J M, et al. Effects on birth weight of smoking, alcohol, caffeine, socioeconomic factors, and psychosocial stress[J]. BMJ,1989, 298(6676):795-801.
[16] ROGERS L K, VELTEN M. Maternal inflammation, growth retardation, and preterm birth: insights into adult cardiovascular disease[J]. Life Sci,2011, 89(13-14):417-421.
[17] TURNER S, PRABHU N,DANIELAN P, et al. First-and second-trimester fetal size and asthma outcomes at age 10 years[J]. Am J Resp Crit Care Med,2011,184(4):407-413.
[18] ELMES M J, GARDNER D S, LANGLEY-EVANS S C. Fetal exposure to a maternal low-protein diet is associated with altered left ventricular pressure response to ischaemia-reperfusion injury[J]. Br J Nutr,2007,98(1):93-100.
[19] TORRENS C, HANSON M A, GLUCKMAN P D, et al. Maternal undernutrition leads to endothelial dysfunction in adult male rat offspring independent of postnatal diet[J]. Br J Nutr,2009,101(1):27-33.
[20] WOODALL S M, JOHNSTON B M, BREIER B H,et al. Chronic maternal undernutrition in the rat leads to delayed postnatal growth and elevated blood pressure of offspring[J]. Pediatr Res,1996,40(3):438-443.
[21] ALEXANDER B T. Placental insufficiency leads to development of hypertension in growth-restricted offspring[J]. Hypertension,2003,41(3):457-462.
[22] BASERGA M, HALE M A, WANG Z M, et al. Uteroplacental insufficiency alters nephrogenesis and downregulates cyclooxygenase-2 expression in a model of IUGR with adult-onset hypertension[J]. Am J Physiol Regul Integr Comp Physiol,2007,292(5):R1943-R1955.
[23] BRENNER B M,GARCIA D L,ANDERSON S.Glomeruli and blood pressure.Less of one, more the other?[J]. Am J Hypertens,1988,1(4 Pt 1):335-347.
[24] ORTIZ ESPEJO M,GIL CAMPOS M,MUNOZ VILLANUEVA M C,et al. Metabolic changes in prepuberty children with extrauterine growth restriction[J].An Pediatr(Barc), 2012,77(4):247-253.
[25] BARKER D J, OSMOND C, FORSON T J,et al.Trajectories of growth among children who have coronary events as adults[J]. N Engl J Med,2005,353(17):1802-1809.
[26] ERIKSSON J,FORSEN T,TUOMILEHTO J,et al.Fetal and childhood growth and hypertension in adult life[J]. Hypertension,2000,36(5):790-794.
[27] SINGHAL A, COLE T J, FEWTRELL M, et al. Promotion of faster weight gain in infants born small for gestational age: is there an adverse effect on later blood pressure?[J]. Circulation,2007,115(2):213-220.
[28] NICHOLAS K R, HARTMANN P E. Milk secretion in the rat: progressive changes in milk composition during lactation and weaning and the effect of diet[J]. Comp Biochem Physiol A Comp Physiol,1991,98(3-4):535-542.
[29] O'DOWD R, KENT J C, MOSELEY J M, et al. Effects of uteroplacental insufficiency and reducing litter size on maternal mammary function and postnatal offspring growth[J]. Am J Physiol Regul Integr Comp Physiol,2008,294(2):R539-548.
[30] DESAI M, GAYLE D, BABU J, et al. Programmed obesity in intrauterine growth-restricted newborns: modulation by newborn nutrition[J]. Am J Physiol Regul Integr Comp Physiol,2005,288(1):R91-96.
[31] TOSH D N, FU Q, CALLAWAY C W, et al. Epigenetics of programmed obesity: alteration in IUGR rat hepatic IGF1 mRNA expression and histone structure in rapid vs. delayed postnatal catch-up growth[J]. Am J Physiol Gastrointest Liver Physiol, 2010,299(5):G1023-1029.
[32] CLEAL J K, POORE K R, BOULLIN J P, et al.Mismatched pre-and postnatal nutrition leads to cardiovascular dysfunction and altered renal function in adulthood[J]. Proc Natl Acad Sci U S A,2007,104(22):9529-9533.
[33] TARE M,PARKINGTON H C, BUBB K J, et al. Uteroplacental insufficiency and lactational environment separately influence arterial stiffness and vascular function in adult male rats[J]. Hypertension, 2012,60(2):378-386.
[34] TARRY-ADKINGS J L, MARTIN-GRONERT M S, FERNANDEZ-TWINN D S,et al. Poor maternal nutrition followed by accelerated postnatal growth leads to alterations in DNA damage and repair, oxidative and nitrosative stress,and oxidative defense capacity in rat heart[J]. FASEB J, 2013,27(1):379-390.
[35] BOL V,DESJARDINGS F,REUSENS B,et al. Does early mismatched nutrition predispose to hypertension and atherosclerosis, in male mice?[J]. PLoS One, 2010, 5(9). pii: e12656.
[36] ZHANG L, TANG L, WEI J, et al. Extrauterine growth restriction on pulmonary vascular endothelial dysfunction in adult male rats: the role of epigenetic mechanisms[J]. J Hypertens, 2014,32(11):2188-2198; discussion 2198.
[37] ROSEBOOM T,DE ROOIJ S,PAINTER R.The Dutch famine and its long-term consequences for adult health[J]. Early Hum Dev,2006,82(8):485-491.
[38] STANNER S A, YUDKIN J S.Fetal programming and the Leningrad Siege study[J]. Twin Res,2001,4(5):287-292.

[1] WANG Xiaoling,OUYANG Xumei,SUN Xiaoyi. Application of mesenchymal stem cells in antineoplastic drugs delivery for tumor-targeted therapy[J]. Journal of ZheJiang University(Medical Science), 2018, 47(5): 525-533.
[2] HU Caiqin,ZHU Biao. Progress on pathogenesis of progressive multifocal leukoence-phalopathy[J]. Journal of ZheJiang University(Medical Science), 2018, 47(5): 534-540.
[3] SHI Ting,YE Xiujin. Roles of CCAAT enhancer binding protein α in acute myeloblastic leukemia[J]. Journal of ZheJiang University(Medical Science), 2018, 47(5): 552-557.
[4] LI Gaopeng,HE Jia,WANG Qingqing. Progress on cancer associated fibroblasts in tumor immunoregulation[J]. Journal of ZheJiang University(Medical Science), 2018, 47(5): 558-563.
[5] YE Jianyu,SUN Ziyu,HU Weiwei. Roles of astrocytes in cerebral infarction and related therapeutic strategies[J]. Journal of ZheJiang University(Medical Science), 2018, 47(5): 493-498.
[6] ZHANG Lifeng,ZHANG Xinmei. Research progress on roles of vitamin D in endometriosis[J]. Journal of ZheJiang University(Medical Science), 2018, 47(4): 413-418.
[7] HE Jiayi,ZHANG Xinmei. Research progress on oxidative stress in pathogenesis of endometriosis[J]. Journal of ZheJiang University(Medical Science), 2018, 47(4): 419-425.
[8] XU Zhili,CUI Yiyi,LI Yan,GUO Yong. Research progress on nonspecific immune microenvironment in breast cancer[J]. Journal of ZheJiang University(Medical Science), 2018, 47(4): 426-434.
[9] WANG Xingxing,WANG Panpan,YANG Xuyan. Research progress on systemic lupus erythematosus overlapping organ-specific autoimmune diseases[J]. Journal of ZheJiang University(Medical Science), 2018, 47(4): 435-440.
[10] WANG Wei,LIU Zhen,LIU Jun,ZHEN Ping,LI Xusheng,SONG Mingjia. Choice of total knee arthroplasty: posterior cruciate ligament preserved or not[J]. Journal of ZheJiang University(Medical Science), 2018, 47(3): 313-319.
[11] QIAN Bo,ZHANG Yanling,MO Xuming. Research progress on transcription factors and signal pathways involved in congenital esophageal atresia[J]. Journal of ZheJiang University(Medical Science), 2018, 47(3): 239-243.
[12] TIAN Guangfeng,GAO Hui,HU Shasha,SHU Qiang. Research progress on genetic and epigenetic mechanisms in congenital heart disease[J]. Journal of ZheJiang University(Medical Science), 2018, 47(3): 227-238.
[13] CHEN Ting,ZHAO Zhengyan,JIANG Pingping,SHU Qiang. Research progress on phenotype and genotype of hyperphenylalaninemia[J]. Journal of ZheJiang University(Medical Science), 2018, 47(3): 219-226.
[14] ZHANG Xiaoyan,KANG Lijun. Molecular and cell biological mechanism of olfactory adaptation in Caenorhabditis elegans[J]. Journal of ZheJiang University(Medical Science), 2018, 47(3): 307-312.
[15] LI Fushan,FANG Ran,RAO Lin,MENG Feilong,ZHAO Xiaoli. Research progress on exosomes in diagnosis and treatment of cardiovascular diseases[J]. Journal of ZheJiang University(Medical Science), 2018, 47(3): 320-326.