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Journal of ZheJiang University(Medical Science)  2015, Vol. 44 Issue (3): 339-343    DOI: 10.3785/j.issn.1008-9292.2015.05.16
    
Research advances on prenatal maternal serum markers for screening adverse pregnancy outcomes
SHEN Qin-qin1, ZHANG Tan2
1. The Medical College of Ningbo University, Ningbo 315211, China;
2. Ningbo Women and Children's Hospital, Ningbo 315012, China
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Abstract  

The routine prenatal maternal serum testing is widely used for screening of birth defects, including Down syndrome, trisomy 18 syndrome and neural tube defects. The testing results are also associated with other adverse pregnant outcomes such as fetal surface structural abnormalities, gestational hypertension disease, intrahepatic cholestasis of pregnancy, premature rupture of membranes, abortion, stillbirth, intrauterine growth restriction and macrosomia; therefore the abnormal levels of serum markers might be used for predicting these adverse pregnant outcomes.



Key wordsPrenatal diagnosis      Biological markers      Pregnancy-associated plasma protein-A      Alpha-fetoproteins      Chorionic gonadotropin      Estriol      Inhibins      Pregnancy outcome     
Received: 06 January 2015      Published: 25 May 2015
CLC:  R715  
Cite this article:

SHEN Qin-qin, ZHANG Tan. Research advances on prenatal maternal serum markers for screening adverse pregnancy outcomes. Journal of ZheJiang University(Medical Science), 2015, 44(3): 339-343.

URL:

http://www.zjujournals.com/med/10.3785/j.issn.1008-9292.2015.05.16     OR     http://www.zjujournals.com/med/Y2015/V44/I3/339


产前筛查血清学指标与不良妊娠结局关系的研究进展

常规应用于出生缺陷二级预防的孕妇产前筛查血清学指标除了可以预测唐氏综合征、18三体综合征和神经管畸形外,还与其他不良妊娠如胎儿体表及结构异常、妊娠期高血压疾病、妊娠期肝内胆汁淤积症、胎膜早破、流产、死胎、早产、胎儿宫内生长受限及巨大儿等存在一定的相关性。提示异常的产前筛查血清学指标还具有其他不良妊娠结局的预示作用。


关键词: 产前诊断,  生物学标记,  妊娠相关血浆蛋白A,  甲胎蛋白类,  人绒毛膜促性腺激素,  雌三醇,  抑制素类,  妊娠结局 

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