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J Zhejiang Univ (Med Sci)  2014, Vol. 43 Issue (5): 602-    DOI: 10.3785/j.issn.1008-9292.2014.09.019
    
Progress in the effects of BRAP gene on cardiovascular diseases
LV Duo, ZHU Yi-min
Department of Public Health, Zhejiang University School of Medicine, Hangzhou 310058, China
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Abstract  

BRAP (BRCA1 associated protein) is one of BRCA1 (Breast cancer suppressor protein) associated cytoplasmic proteins. BRAP gene has been found to be associated with the risk of some cancers, and the associations between BRAP and cardiovascular diseases and metabolic syndrome is gradually attracting much attention. However, the explicit mechanisms involved remain to be fully elucidated. We reviewed the association between BRAP gene and cardiovascular diseases and metabolic syndromes and the biologic mechanisms in the regulation of metabolism, hoping to provide clues on our future researches.



Key wordsBRCA1 protein      Genes, BRCA1      Metabolic diseases      Cardiovascular diseases      Stroke      Syndrome      Review     
Received: 19 March 2014      Published: 18 April 2014
Corresponding Authors: ZHU Yimin, E-mail: zhuym@zju.edu.cn   
Cite this article:

LV Duo, ZHU Yi-min. Progress in the effects of BRAP gene on cardiovascular diseases. J Zhejiang Univ (Med Sci), 2014, 43(5): 602-.

URL:

http://www.zjujournals.com/med/10.3785/j.issn.1008-9292.2014.09.019     OR     http://www.zjujournals.com/med/Y2014/V43/I5/602


BRAP基因与心脑血管疾病和代谢综合征研究进展

BRAP(BRCA1 associated protein)是乳腺癌易感基因BRCA1(breast cancer suppressor protein)的一种相关蛋白质。BRAP基因与多种肿瘤易感性的研究较多,而与心脑血管疾病和代谢综合征的关系也逐渐受到关注。本文系统总结了近年来BRAP基因多态性与心血管疾病和代谢综合征等疾病易感性的关系及其在代谢调节方面可能的作用机制的研究结果,以期为将来的研究提供线索。


关键词: BRCA1蛋白质,  基因,  BRCA1,  代谢疾病,  心血管疾病,  卒中,  综合征,  综述 
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