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Journal of ZheJiang University(Medical Science)  2014, Vol. 43 Issue (4): 494-500    DOI: 10.3785/j.issn.1008-9292.2014.07.010
    
Fourier transform infrared spectroscopy in detection of breast cancer
CHEN Su-han1, LAO Wei-wei1, XU Zao-xian1, LIU Qing2, WEN Huan1, DENG Hong1
1.Zhejiang University School of Medicine, Hangzhou 310058, China; 2. Institute of Analytical Chemistry and Applied Chemistry of Zhejiang University, Hangzhou 310027, China
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Abstract  Breast cancer is the most common cancer in women. Later diagnosis of the disease is the leading cause of poor prognosis. Fourier-transform infrared (FTIR) spectroscopy is a novel approach to provide information about the molecular components and metabolic conditions of human tissue; therefore it can detect the early changes caused by cancer cells prior to histological manifestation. FTIR-based diagnosis is rapid, simple and label free, which meets the requirements of an automated and patient-friendly technique. The current article gives an overview of the experimental techniques, data analysis methods and spectral signatures of breast cancer in FTIR-based diagnosis, summarizes the present challenges by focusing on the history of FTIR spectroscopy in breast cancer since 1990s, and highlights some investigations that give a perspective of FTIR-based diagnosis.

Received: 28 December 2013     
Corresponding Authors: DENG Hong, E-mail: hongdeng@zju.edu.cn   
Cite this article:

CHEN Su-han,et al. Fourier transform infrared spectroscopy in detection of breast cancer . Journal of ZheJiang University(Medical Science), 2014, 43(4): 494-500.

URL:

http://www.zjujournals.com/xueshu/med/10.3785/j.issn.1008-9292.2014.07.010     OR     http://www.zjujournals.com/xueshu/med/Y2014/V43/I4/494


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关键词: 乳腺肿瘤/诊断丨谱学,  傅里叶变换红外丨综述  
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