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Journal of ZheJiang University(Medical Science)  2014, Vol. 43 Issue (4): 453-457    DOI: 10.3785/j.issn.1008-9292.2014.06.002
    
Bioinformatic analysis of pygo1 gene in Homo sapiens
HAO Ai-ping
College of Life Sciences and Technology, Mudanjiang Normal College, Mudanjiang 157012, China
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Abstract  Objective: To analyze the structure and function of PYGO1 protein with bioinformatics. Methods: The bioinformatic methods and tools were used to analyze the physical and chemical properties, transmembrane region, hydrophobicity and hyrdrophilicity, secondary structure and functional category of PYGO1 protein. Results: The bioinformatic analysis revealed that proline content was the highest of all amino acid residues in PYGO1 protein; the molecular formula was C1943H2937N577O635S18 with a relative molecular mass of 45; and the theoretical isoelectric point was 6.38. The analysis also demonstrated that PYGO1 was a hydrophilic and non-transmembrane protein; its main component was alpha-helix and random coil; it contained a plant homeodomain. Conclusion: Human pygo1 gene may act as a transcription regulation factor to regulate the heart development and the progress of heart diseases.

Received: 29 August 2012     
Cite this article:

HAO Ai-ping. Bioinformatic analysis of pygo1 gene in Homo sapiens. Journal of ZheJiang University(Medical Science), 2014, 43(4): 453-457.

URL:

http://www.zjujournals.com/xueshu/med/10.3785/j.issn.1008-9292.2014.06.002     OR     http://www.zjujournals.com/xueshu/med/Y2014/V43/I4/453


人类pygo1基因的生物信息学分析

目的:对人类pygo1基因编码蛋白质进行结构和功能预测。 方法:利用生物信息学方法和工具对PYGO1蛋白质理化性质、跨膜区域、二级结构、亲(疏)水性进行分析。 结果:PYGO1蛋白氨基酸残基组成中脯氨酸含量最高,分子式C1943H2937N577O635S18,相对分子质量45,等电点6.38;可能为非跨膜的亲水性蛋白;α-螺旋和无规卷曲为其主要结构元件,含有一个植物同源结构域。 结论:人类pygo1基因可能作为转录因子与其他蛋白共同作用调节心脏发育及心脏病的发生过程。

关键词: 人丨pygo1基因丨生物信息学丨氨基酸类/生物合成丨蛋白质类/生理学,  蛋白质类/化学丨蛋白质结构, 二级丨基因丨计算生物学丨序列分析  
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