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Journal of ZheJiang University(Medical Science)  2014, Vol. 43 Issue (1): 109-114    DOI: 10.3785/j.issn.1008-9292.2014.01.004
    
Nicotinamide phosphoribosyltransferase and its roles in cancer
1.Department of Thoracic Surgery,Zhejiang Cancer Hospital,Hangzhou 310022,China; 2.Department of Thoracic Surgery,Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310009,China
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Abstract  

Nicotinamide phosphoribosyltransferase (Nampt) is a rate-limiting enzyme for synthesis of nicotinamide adenine dinucleotide in mammalian cells.Recent studies show that Nampt also works as a cytokine that exerts insulin-mimetic effects by binding to the insulin receptor,induces B-cell differentiation,inhibits neutrophil apoptosis,and affects immune and inflammatory functions.This review is focused on current knowledge regarding the structure and function of Nampt and its roles in carcinogenesis.



Received: 15 March 2013      Published: 04 January 2014
Corresponding Authors: WU Ming; E-mail: iwuming@hotmail.com    
Cite this article:

XU Xiao-fang,WU Ming. Nicotinamide phosphoribosyltransferase and its roles in cancer. Journal of ZheJiang University(Medical Science), 2014, 43(1): 109-114.

URL:

http://www.zjujournals.com/xueshu/med/10.3785/j.issn.1008-9292.2014.01.004     OR     http://www.zjujournals.com/xueshu/med/Y2014/V43/I1/109


烟酰胺磷酸核糖转移酶及其与肿瘤关系研究进展

烟酰胺磷酸核糖转移酶(Nampt)是哺乳动物细胞合成烟酰胺腺嘌呤二核苷酸的限速酶; Nampt也是一种细胞因子,如作为一种新的具有结合并激活胰岛素受体、模拟胰岛素作用的脂肪细胞因子,调控B细胞分化、延缓中性粒细胞凋亡、参与炎症和免疫应答。本文就Nampt的结构、功能及其与肿瘤关系的研究进展作一综述。


关键词: 烟酰胺磷酸核糖转移酶,  肿瘤,  磷酸类,  核糖,  烟酰胺,  综述 
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