Nicotinamide phosphoribosyltransferase and its roles in cancer
1.Department of Thoracic Surgery，Zhejiang Cancer Hospital，Hangzhou 310022，China; 2.Department of Thoracic Surgery，Second Affiliated Hospital，Zhejiang University School of Medicine，Hangzhou 310009，China
Nicotinamide phosphoribosyltransferase (Nampt) is a rate-limiting enzyme for synthesis of nicotinamide adenine dinucleotide in mammalian cells.Recent studies show that Nampt also works as a cytokine that exerts insulin-mimetic effects by binding to the insulin receptor，induces B-cell differentiation，inhibits neutrophil apoptosis，and affects immune and inflammatory functions.This review is focused on current knowledge regarding the structure and function of Nampt and its roles in carcinogenesis.
Received: 15 March 2013
Published: 04 January 2014