" />  " />  " /> 中国儿童青少年性发育现状研究
Please wait a minute...
Journal of ZheJiang University(Medical Science)  2013, Vol. 42 Issue (4): 396-    DOI: 10.3785/j.issn.1008-9292.2013.04.005
    
Epidemiologic study on current pubertal development in Chinese school-aged children
 
ZHU Mingqiang1,FU Junfen1,LIANG Li1,7,GONG Cunxiu2,XIONG Feng3,LIU Geli4,LUO Feihong5,CHEN Shaoke6
1.Children′s Hospital,Zhejiang University School of Medicine,Hangzhou 310003; 2.Beijing Children′s Hospital of Capital Medical University,Beijing 100045; 3.Children′s Hospital of Chongqing Medical University,Chongqing 400014; 4.General Hospital of Tianjin Medical University,Tianjin 300052; 5.Children′s Hospital of Shanghai Fudan University,Shanghai 200032; 6.Maternal and Child Health Care Institute of Guangxi Zhuang Autonomous Region,Guangxi 530003;7.Department of Pediatrics,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003
Download: HTML (   PDF(993KB)
Export: BibTeX | EndNote (RIS)      

Abstract  

Abstract]Objective: To survey the current status of pubertal development of Chinese children and to compare the precocious puberty prevalence of different regions. Methods: A cross-sectional epidemiological study was conducted on 18 707 children and adolescents aged 6~18 y with male/female ratio of 9 812/8 895 from 6 representative geographical areas in China,including Beijing,Tianjin,Hangzhou,Shanghai,Chongqing and Nanning.The height,weight,waist circumference (WC),hip circumference(HC) and sexual maturation states (Tanner stages:breast stages for girls and testicular volume for boys) of children and adolescents were measured.Probit analysis was used to calculate the median age and 95%confidence interval (CI) for onset of breast and testicular development.The prevalence of precocious puberty of different regions and BMI,waist circumference of different groups were compared. Results: Breast development before 8 y was observed in 2.91%of girls,and testicular volume 4 ml or more before 9 y was observed in 1.74% of boys.The median age of onset of Tanner stages 2 for breast development in girls was 9.69 y (95%CI:9.63~9.75); the median age of onset of puberty as indicated by Tanner stages 2 for testicular development in boys was 11.25 y (95%CI:11.19~11.30).The prevalence of precocious puberty (43 girls and 37 boys) was 0.43% (80/18 707).The prevalence of precocious puberty in northern region was higher than that in southwest region(0.736% vs 0.282%,P<0.05).There was no difference in onset age of precocious puberty in girls among three regions; but the onset age of precocious puberty in boys was earlier in east China [(7.4±0.28)y].The SD values of BMI and waist-to-hip ratio (W/H) in precocious puberty children were higher than those in the peer normal children.There was no difference in BMI,waist circumference and waist-to-hip ratio in the precocious puberty children among different regions. Conclusions: The current diagnostic criteria of precocious puberty are suitable for the children in the survey areas.The prevalence and the onset age of precocious puberty are various in different regions.A positive association between obesity and precocious puberty is found both in boys and girls.



Key wordsObesity/epidemiology      Sexual development      Adolescent development      Precocious puberty      Obesity      China     
Received: 25 March 2013      Published: 07 August 2013
CLC:  R 725.8  
Corresponding Authors: 傅君芬(1968-),女,博士,主任医师,博士生导师,从事儿科内分泌专业     E-mail: fjf68@qq.com
Cite this article:

ZHU Mingqiang,FU Junfen,LIANG Li,GONG Cunxiu,XIONG Feng,LIU Geli,LUO Fei. Epidemiologic study on current pubertal development in Chinese school-aged children

 
. Journal of ZheJiang University(Medical Science), 2013, 42(4): 396-.

URL:

http://www.zjujournals.com/med/10.3785/j.issn.1008-9292.2013.04.005     OR     http://www.zjujournals.com/med/Y2013/V42/I4/396


中国儿童青少年性发育现状研究

[摘要]目的:了解中国儿童青少年性发育现状,比较不同地区性早熟情况。方法:于2009年10月至2010年10月,选择有地域代表的北京、天津、杭州、上海、重庆和南宁六地区6~18岁中小学生共18 707名(男9 812名和女8 895名),按标准化方法测定各年龄组儿童身高、体重、臀围和腰围等数据。采用女性乳房和男性睾丸容积Tanner分期指标衡量青春期发育。采用概率分析法测算男女第二性征出现的年龄中位数及95%可信区间。用精确概率法分析不同地区性早熟发生率,用t检验比较组间不同BMI、腰围计量资料。结果:女孩8岁组以前出现乳房发育的比例为2.91%,男孩9岁以前出现睾丸发育的比例为1.74%。女孩呈现乳房发育B2的中位年龄是9.69(95%CI:9.63~9.75)岁,男孩睾丸达G2期的中位年龄为11.25(95%CI:11.19~11.30)岁。共有80例儿童诊断为性早熟,女孩43例,男孩37例,其患病率为0.43%。北部地区较西南地区发病率高(0.736% vs 0.282%,P<0.05)。三个地区女孩性早熟的发病年龄没有差异,男孩性早熟华东地区发病年龄较早(7.4±0.28)岁。性早熟儿童其BMI的SD值及腰臀比(W/H)较正常同龄儿童高,不同地区性早熟儿童BMI、腰围、腰臀比比较差异均无统计学意义。结论:目前的性早熟诊断标准适合于评估调查地区的儿童性早熟状况。性早熟发病率及发病年龄在不同地区存在一定差异。肥胖与性早熟之间存在正相关。


关键词: 肥胖症/流行病学,  性发育,  青春期发育,  性早熟,  肥胖,  中国 
[1] MAO Xiao-rong, ZHANG Li-ting, JIANG Ni, XIAO Ping, PENG Xue-bin, ZHANG You-cheng. Distribution of HCV genotypes in Chinese Han population with chronic hepatitis C[J]. Journal of ZheJiang University(Medical Science), 2015, 44(4): 417-422.
[2] WANG Anru,YANG Fangling YU Baosheng,SHAN Ye,GAO Lanying,ZHANG Xiaoxiao,PENG Ya. Hand and wrist bone maturation in children with central precocious puberty and idiopathic short stature[J]. Journal of ZheJiang University(Medical Science), 2013, 42(4): 411-.
[3] LI Rong,XIONG Feng,HU Yujuan,HOU Ling,CHENG Xinran,LUO Yanhong,MA Qinxiang. Survey on quality of life in children and adolescents with type 1 diabetes[J]. Journal of ZheJiang University(Medical Science), 2013, 42(4): 388-.
[4] LIN Hu,FU Junfen,CHEN Xuefeng,HUANG Ke,WU Wei,LIANG Li. Early identification of impaired renal function in obese children with non-alcoholic fatty liver disease[J]. Journal of ZheJiang University(Medical Science), 2013, 42(4): 381-.
[5] CHEN Lianhui,LIANG Li,FU Junfen,ZHU Weifen,WANG Chunlin,HUANG Ke,FANG Yan. Comparison of clinical application of two definitions of metabolic syndrome in children and adolescents[J]. Journal of ZheJiang University(Medical Science), 2013, 42(4): 375-.
[6] . Screening of differentially expressed genes during adipocyte differentiation by suppression subtractive hybridization technique[J]. Journal of ZheJiang University(Medical Science), 2012, 41(3): 267-273.
[7] . Research progress on nicotinamide phosphoribosyl transferase involved in aging and age-related diseases[J]. Journal of ZheJiang University(Medical Science), 2011, 40(6): 680-684.