Please wait a minute...
Journal of ZheJiang University(Medical Science)  2012, Vol. 41 Issue (3): 305-309    DOI:
    
Serum sCD44v6 and sE-cadherin levels in patients with esophageal squamous cell carcinoma
HE Ying,ZHANG Jun,WANG Shu-kui,HUANG Wen-bin,CHEN Xin-guo,HE Bang-shun,ZHAO You-cai,WANG Jin-song
Nanjing First Hospital,Nanjing Medical University,Nanjing 210006,China
Download: HTML (   PDF(1101KB)
Export: BibTeX | EndNote (RIS)      

Abstract  Objective: To investigate the serum levels of sCD44v6 and sE-cadherin (sE-cad) in patients with esophageal squamous cell carcinoma.
Methods: The serum samples were collected from 65 cases of esophageal squamous cell carcinoma,32 cases of erosive esophagitis and 35 healthy subjects.Serum sCD44v6 and sE-cad levels were measured by enzyme linked immunosorbent assay (ELISA).
Results: The mean levels of serum sCD44v6 and sE-cad in esophageal squamous cell carcinoma patients were significantly higher than those of erosive esophagitis patients and normal controls (both P<0.05).There was no significant difference in serum sCD44v6 and sE-cad levels between erosive esophagitis patients normal controls (P=0.566 and P=0.708,respectively).Serum sCD44v6 and sE-cad levels of esophageal cancer patients were not correlated with their clinicopathological features.Serum sCD44v6 level is not correlated with sE-cad level in squamous cell carcinoma patients(P=0.651).
Conclusion: Serum sCD44v6 and sE-cad might be a potential marker for screening of esophageal squamous cell carcinoma.


Key wordsEnzyme-linked immunosorbent assay; Gene expression; Cadherins/analysis; Esophageal neoplasms; Neoplasms      squamous cell; Antigens      CD44/analysis     
Published: 25 May 2012
Cite this article:

. Serum sCD44v6 and sE-cadherin levels in patients with esophageal squamous cell carcinoma. Journal of ZheJiang University(Medical Science), 2012, 41(3): 305-309.

URL:

http://www.zjujournals.com/med/     OR     http://www.zjujournals.com/med/Y2012/V41/I3/305


食管鳞癌患者血清中可溶性CD44v6和E-钙黏蛋白表达的临床意义

目的:检测食管鳞癌患者血清中可溶性CD44v6(sCD44v6)和可溶性E-钙黏蛋白(sE-cadherin,sE-cad)的表达,探讨这2种可溶性黏附分子表达与食管鳞癌临床病理特征的关系以及这2种可溶性黏附分子在血清中表达的相关性。
方法:采集65例食管鳞癌患者、32例糜烂性食管炎患者和35例正常食管者的血清,采用酶联免疫吸附法(ELISA)检测血清中sCD44v6、sE-cad的表达,并与其临床病理资料对照。
结果:血清sCD44v6在食管鳞癌组表达水平明显高于正常食管组及糜烂性食管炎组(P<0.05),正常食管组与糜烂性食管炎组比较无统计学差异(P=0.566);血清sCD44v6水平与食管鳞癌临床病理特征无关。 血清sE-cad水平在食管鳞癌组明显高于正常食管组及糜烂性食管炎组(P<0.05),正常食管组与糜烂性食管炎组比较无统计学差异(P=0.708);血清sE-cad水平与食管鳞癌临床病理特征无关。 食管鳞癌患者血清中sCD44v6和sE-cad水平无显著相关性(r=-0.057,P=0.651)。
结论:血清sCD44v6及sE-cad水平测定有望成为筛查食管鳞癌的血清学指标。

关键词: 酶联免疫吸附测定,  基因表达,  钙黏着糖蛋白类/分析,  食管肿瘤,  肿瘤,  鳞状细胞,  抗原,  CD44/分析 
No related articles found!