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Journal of ZheJiang University(Medical Science)  2011, Vol. 40 Issue (5): 559-566    DOI:
    

HIF-1 signal pathway in cellular response to hypoxia
WANG Ping-ping,KONG Fan-ping,CHEN Xue-qun,DU Ji-zeng
Department of Basic Medical Sciences,Zhejiang University School of Medicine,Hangzhou 310058,China
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Abstract  HIF-1 is composed of HIF-1α and HIF-1β subunits. It promotes target genes transcription under hypoxia and plays essential roles in cell development, physiological adaptations, and pathological processes. In the past 10 years, the research on signaling pathways of HIF-1 in response to cell hypoxia stress, especially on HIF-1α-mediated gene transcription has made great progress.

Key wordsHypoxia-inducible factor 1      Hypoxia      Response elements      Transcription factors     
Published: 25 September 2011
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HIF-1 signal pathway in cellular response to hypoxia. Journal of ZheJiang University(Medical Science), 2011, 40(5): 559-566.

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http://www.zjujournals.com/med/     OR     http://www.zjujournals.com/med/Y2011/V40/I5/559


低氧细胞应激的HIF-1信号通路

低氧诱导因子(hypoxia inducible factor,HIF)由HIF-1α和HIF-1β两个亚基组成,在低氧下其能激活多种靶基因的转录,在细胞、组织生长发育和生理应激,以及某些病理过程中具有重要的作用。近10年来,有关HIF-1在细胞低氧应激时的信号转导通路,特别是HIF-1α介导的基因转录调控的研究取得了巨大进展。

关键词: 低氧诱导因子1,  低氧,  反应元件,  转录因子 
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