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Journal of ZheJiang University(Medical Science)  2008, Vol. 37 Issue (6): 634-637    DOI: 10.3785/j.issn.1008-9292.2008.06.015
    
T lymphocyte subgroups and serum levels of trace elements in patients with diarrhea type of irritable bower syndrome
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Published: 25 November 2008
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. T lymphocyte subgroups and serum levels of trace elements in patients with diarrhea type of irritable bower syndrome. Journal of ZheJiang University(Medical Science), 2008, 37(6): 634-637.

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http://www.zjujournals.com/med/10.3785/j.issn.1008-9292.2008.06.015     OR     http://www.zjujournals.com/med/Y2008/V37/I6/634


腹泻型肠易激综合征患者外周血T淋巴细胞亚群及血清微量元素含量变化研究

目的:通过测定腹泻型肠易激综合征(D-IBS)患者外周血T淋巴细胞亚群及血清Zn、Se、Fe、Cu含量变化,旨在探讨IBS的可能病因及发病新机制.方法:随机抽取30例D-IBS患者和30例健康志愿者的外周血标本,采用流式细胞技术,分别测定CD3、CD4、CD8 T淋巴细胞亚群百分比,并计算CD4/CD8比值;采用原子吸收光谱法,测定血清Zn、Fe、Cu水平,用原子荧光分析法,测定血清Se水平.结果:D-IBS组外周血CD4 T淋巴细胞水平及CD4/CD8比值较正常对照组明显降低(P<0.01);D-IBS组与正常组血清Zn、Se、Fe、Cu水平差异无统计学意义(P>0.05).结论:外周血T淋巴细胞CD4水平及CD4/CD8比值降低提示D-IBS患者可能存在细胞免疫异常;D-IBS患者血清Zn、Se、Fe、Cu水平较正常对照组无统计学意义.


关键词: 肠易激综合征/免疫学,  T淋巴细胞亚群/免疫学,  腹泻/病因学,  腹泻型肠易激综合征,  微量元素 
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