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J Zhejiang Univ (Med Sci)  2021, Vol. 50 Issue (2): 222-228    DOI: 10.3724/zdxbyxb-2021-0124
    
Immune mechanisms involved in the coexistence of oral lichen planus and autoimmune thyroid diseases
WANG Yahui(),HAO Yilong,TANG Fan,CHEN Qianming()
Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine & Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou 310006, China
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Abstract  

Oral lichen planus (OLP) is a chronic inflammatory oral mucosal disease with unclear etiology. Autoimmune thyroid diseases (AITD) is a type of autoimmune disease characterized by increased thyroid-specific antibodies. In recent years, more and more studies have found that the incidence of AITD is increased in OLP patients. The occurrence and development of OLP and AITD may be related to the expression of thyroid autoantigen in oral keratinocytes, the imbalance of thyroid hormone (Th)1/Th2 and Th17/Treg cell subsets, the abnormal quantity and function of follicular helper T cells and chemokines and the specific killing ability of CD8+ T cells to target cells. In this article, the possible immune mechanisms involved in the coexistence of OLP and AITD are reviewed to provide insights for the diagnosis, treatment and prevention of these two diseases from the perspective of immunology.



Key wordsOral lichen planus      Autoimmune thyroid disease      Hashimoto disease      Graves disease      Pathogenesis      Immunology     
Received: 01 February 2021      Published: 18 June 2021
CLC:  R781.5  
  R581  
Corresponding Authors: CHEN Qianming     E-mail: yhwang9703@163.com;qmchen@zju.edu.cn
Cite this article:

WANG Yahui,HAO Yilong,TANG Fan,CHEN Qianming. Immune mechanisms involved in the coexistence of oral lichen planus and autoimmune thyroid diseases. J Zhejiang Univ (Med Sci), 2021, 50(2): 222-228.

URL:

http://www.zjujournals.com/med/10.3724/zdxbyxb-2021-0124     OR     http://www.zjujournals.com/med/Y2021/V50/I2/222


口腔扁平苔藓与自身免疫性甲状腺疾病共存的免疫机制探讨

口腔扁平苔藓(OLP)是一种病因尚未完全明确的慢性炎症性口腔黏膜疾病。自身免疫性甲状腺疾病(AITD)是一类以甲状腺特异性抗体异常增多为特点的自身免疫性疾病。近年来,越来越多的研究表明,临床上 OLP 患者伴发 AITD 的概率呈上升趋势。两者的发生发展可能与口腔角质形成细胞表达甲状腺自身抗原、辅助性 T 细胞(Th)1/Th2 和 Th17/调节性T 细胞亚群的失衡、滤泡 Th 细胞和趋化因子数量及功能异常以及 CD8+ T 细胞特异性杀伤靶细胞等有关。本文就 OLP 与 AITD 可能共存的免疫机制作一综述,以期从免疫学角度为两者的诊疗提供思路。


关键词: 口腔扁平苔藓,  自身免疫性甲状腺疾病,  桥本甲状腺炎,  格雷夫斯病,  发病机制,  免疫学 
Figure 1 The immunological mechanism of oral lichen planus and autoimmune thyroid disease实线代表已证实,虚线代表尚未证实.T3:三碘甲腺原氨酸;T4:甲状腺素;GD:格雷夫斯病;HT:桥本甲状腺炎;CTL:细胞毒性T淋巴细胞;TSH:促甲状腺激素;TSHR:促甲状腺激素受体;TRAb:促甲状腺激素受体抗体;TGAb:甲状腺球蛋白抗体;TPO:甲状腺过氧化物酶;TPOAb:甲状腺过氧化物酶抗体;ADCC:抗体依赖性细胞介导的细胞毒作用;TNF:肿瘤坏死因子;IL:白介素;Th:辅助 T 性细胞;Tfh:滤泡辅助性 T 细胞;Treg:调节性 T 细胞;RANTES:T 细胞激活性低分泌因子;CXCL:趋化因子CXC亚家族配体;CXCR:趋化因子CXC亚家族受体.
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