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J Zhejiang Univ (Med Sci)  2021, Vol. 50 Issue (1): 123-130    DOI: 10.3724/zdxbyxb-2021-0030
The role of neutrophils in asthma
CHEN Fei(),YU Min,ZHONG Yonghong,HUA Wen,HUANG Huaqiong()
Department of Respiratory and Critical Care Medicine,the Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310009,China
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Bronchial asthma is a chronic respiratory disease,characterized by airway inflammation,airway hyperresponsiveness,reversible airway obstruction and airway remodeling,in which a variety of cells including airway inflammatory cells and structural cells are involved. Previous studies have shown that asthma is mainly driven by Th2 cytokines IL-4,IL-5,and IL-13,leading to airway eosinophil inflammation. With further research,however,it has been found that neutrophils are also closely related to asthma. Numbers of neutrophils are elevated in airway through increased chemotaxis and decreased apoptosis,which is earlier than eosinophils,leading to airway neutrophilic inflammation. Neutrophils can produce elastase,myeloperoxidase,neutrophil extra- cellular traps,chemokines and cytokines,participating in the occurrence and development of asthma. The antagonists against these molecules,such as anti-IL-8 receptor antibody,anti-IL-17 antibody,and DNase,have shown positive effects on neutrophilic asthma,but further studies are needed to support their clinical application. This article mainly reviews the role of neutrophils in asthma and related mechanisms.

Key wordsNeutrophils      Asthma      Neutrophilic asthma      Therapy; Review     
Received: 14 September 2020      Published: 14 May 2021
CLC:  R562.1  
Corresponding Authors: HUANG Huaqiong     E-mail:;
Cite this article:

CHEN Fei,YU Min,ZHONG Yonghong,HUA Wen,HUANG Huaqiong. The role of neutrophils in asthma. J Zhejiang Univ (Med Sci), 2021, 50(1): 123-130.

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关键词: 中性粒细胞,  哮喘,  中性粒细胞哮喘,  治疗; 综述 
Figure 1 Molecular mechanisms of neutrophils in asthma
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