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Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2009, Vol. 10 Issue (7): 505-511    DOI: 10.1631/jzus.B0820370
Biomedicine     
Effects of carnosine on the evoked potentials in hippocampal CA1 region
Zhou-yan FENG, Xiao-jing ZHENG, Jing WANG
Key Lab of Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310003, China
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Abstract  Objective: To directly examine the effects of carnosine on neuronal excitation and inhibition in rat hippocampus in vivo. Methods: Artificial cerebrospinal fluid with carnosine was directly administrated over the exposed rat hippocampus. The changes of neuron activity in the CA1 region of hippocampus were evaluated by orthodromically- and antidromically-evoked potentials, as well as paired-pulse stimulation paradigm. Results: In both orthodromic and antidromic response potentials, carnosine transformed population spikes (PSs) with single spike into epileptiform multiple spikes. In addition, similar to the effect of (-aminobutyric acidA (GABAA) antagonist picrotoxin, carnosine decreased paired-pulse stimulating depression significantly. However, no significant change was observed in the spontaneous field potentials during the application of carnosine. Conclusion: The results indicate a disinhibition-induced excitation effect of carnosine on the CA1 pyramidal neurons. It provides important information against the application of carnosine as a potential anticonvulsant in clinical treatment.

Key wordsCarnosine      Hippocampus      Evoked potential      Epileptic seizure     
Received: 22 November 2008     
CLC:  R742  
Cite this article:

Zhou-yan FENG, Xiao-jing ZHENG, Jing WANG. Effects of carnosine on the evoked potentials in hippocampal CA1 region. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2009, 10(7): 505-511.

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http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B0820370     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2009/V10/I7/505

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