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浙江大学学报(工学版)
J4  2013, Vol. 47 Issue (12): 2160-2164    DOI: 10.3785/j.issn.1008-973X.2013.12.013
化学工程     
离子液体复合溶剂法制备纤维素多孔微球
王鹏, 林东强, 姚善泾
化学工程联合国家重点实验室,浙江大学 化学工程与生物工程学系,浙江 杭州 310027
Preparation of porous cellulose beads with ionic liquid mixed solvent
WANG Peng, LIN Dong-qiang, YAO Shan-jing
State Key Laboratory of Chemical Engineering, Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China
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摘要：

针对传统纤维素溶解方法的局限性,以离子液体1-丁基-3-甲基咪唑氯盐（BmimCl）和有机溶剂1,3-二甲基-2-咪唑啉酮（DMI）组成的复合溶剂溶解微晶纤维素,结合反相悬浮再生法,制备纤维素多孔微球.考察复合溶剂配比对纤维素溶解度和微球制备的影响,比较分析了微球的理化性质,结果表明：所制微球体现出良好的球形度、孔度、孔径和比表面积；进一步选择合适微球,偶联离子交换配基,制备阴离子交换介质,体现出良好的蛋白吸附性能.采用复合溶剂法制备纤维素多孔微球,过程简便,性能优良,可以作为层析介质制备的新方法.
Abstract:

Aiming at the limitation of cellulose dissolution with the traditional methods, microcrystalline cellulose was dissolved in the mixed solvent of 1-buthy-3-methylimidazolium chloride (BmimCl) and 1,3-dimethyl-2-imidazolidinone (DMI).
Porous cellulose beads were prepared with the method of water-in-oil suspension regeneration. The influences of solvent proportion on the dissolubility of cellulose and bead preparation were investigated. Physical properties of the beads were characterized, and the cellulose beads showed good sphericity, porosity, pore diameter and specific surface area. Furthermore, cellulose beads were functionalized to prepare anion exchanger and good adsorption performance was found. The results indicated that the developed method has the advantage of process robustness and can be used as a new method to prepare cellulose matrices for the chromatographic separation.
出版日期: 2013-12-01
:  TQ 31  
基金资助:

 国家自然科学基金资助项目（21036005,21276228)；高等学校博士学科点专项科研基金资助项目（20100101110044）；浙江省自然科学基金资助项目（LR12B06003）.
通讯作者: 林东强,男,教授,博导.     E-mail: lindq@zju.edu.cn
作者简介: 王鹏（1987—）,男,硕士生,从事生物分离过程研究. E-mail: 06swgcwp@zju.edu.cn
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引用本文:

王鹏, 林东强, 姚善泾. 离子液体复合溶剂法制备纤维素多孔微球[J]. J4, 2013, 47(12): 2160-2164.

WANG Peng, LIN Dong-qiang, YAO Shan-jing. Preparation of porous cellulose beads with ionic liquid mixed solvent. J4, 2013, 47(12): 2160-2164.

链接本文:

http://www.zjujournals.com/eng/CN/10.3785/j.issn.1008-973X.2013.12.013    或    http://www.zjujournals.com/eng/CN/Y2013/V47/I12/2160

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