RNA甲基化修饰N6-甲基腺苷调控病毒感染的研究进展
Research advances on the regulation of viral infection by N6-methyladenosine of RNA methylation modification
RNA甲基化修饰N6-甲基腺苷调控病毒感染的研究进展 |
| 吉春苗,黄耀伟 |
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Research advances on the regulation of viral infection by N6-methyladenosine of RNA methylation modification |
| Chunmiao JI,Yaowei HUANG |
| 图1 m6A修饰的分子机制和功能WTAP：肾母细胞瘤1相关蛋白；METTL3：甲基转移酶样蛋白3；METTL14：甲基转移酶样蛋白14；RBM15/15B：RNA结合基序蛋白15/15B；VIRMA：病毒样m6A甲基转移酶相关蛋白；ZC3H13：包含CCCH锌指结构域蛋白13；FTO：脂肪与肥胖相关蛋白；ALKBH5：AlkB同源蛋白5；hnRNPA2/B1：核内不均一核糖核蛋白A2/B1；FMRP：脆性X智力障碍蛋白；IGF2BP：胰岛素生长因子2结合蛋白；eIF3：真核起始因子3。 |
| Fig. 1 Molecular mechanisms and functions of m6A modificationWTAP: Wilms tumor 1-associated protein; METTL3: Methyltransferase like 3; METTL14: Methyltransferase like 14; RBM15/15B: RNA binding motif protein 15/15B; VIRMA:Virus like m6A methyltransferase associated protein; ZC3H13: Zinc finger CCCH domain-containing protein 13; FTO: Fat mass and obesity-associated protein; ALKBH5: AlkB homolog 5; hnRNPA2/B1: Heterogeneous nuclear ribonucleoprotein A2/B1; FMRP: Fragile X mental retardation protein; IGF2BP: Insulin like growth factor 2 binding protein; eIF3: Eukaryotic initiation factor 3. |
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