To investigate the long-term effects of zinc-silicon (Zn-Si) on mineral element translocation from root to shoot of rice under cadmium (Cd) stress, we performed this experiment using two rice genotypes (Xiushui 110 and HIPJ 1) with eight combination treatments of three Si levels (0, 5 and 15 μmol/L Na₂SiO₃·9H₂O), three Zn levels (0, 1 and 10 μmol/L ZnSO₄·7H₂O) and two Cd levels (0 and 15 μmol/L CdCl₂). Data on plant biomass, photosynthesis, antioxidant enzyme activity, lipid peroxidation and mineral element concentrations were analyzed. The combination treatments of Cd (15 μmol/L) and Si (15 μmol/L) or Zn (10 μmol/L) resulted in higher shoot height and root length in both the genotypes as compared with the Cd (15 μmol/L) treatment. Analysis of dry mass showed that the sole Zn alleviation was more effective on biomass increase than the sole Si in both the genotypes. The malondialdehyde (MDA) content in leaf dropped across all alleviation treatments in both the genotypes; Xiushui 110 had higher overall leaf catalase activity than HIPJ 1. The sole Zn and Si and the Zn-Si alleviation treatments reduced Cd translocation factor (TF) from root to shoot in HIPJ 1 but not in Xiushui 110. Analysis of TFs showed that Cd significantly reduced the movement of elements such as Ca, Mn and Mg. Zn alone treatment increased plant growth more than Si alone and Zn-Si treatments. However, Zn-Si treatment was not effective on improving mineral element uptake in Cd stressed plants.